South Carolina has three principal regions: the coastal region, which has Myrtle Beach and is known for its golf courses as well as beautiful beaches; the historic city of Charleston, with its cobblestone streets and historic waterfront area; and Greenville, located in the Upstate region, which is known for outdoor activities and mountain towns. The Midlands (Piedmont) region is home to the state capital of Columbia and Lake Murray, which is a popular destination for fishing enthusiasts. Charleston and Columbia are the largest cities in the state and where the majority of banks are based and operate. The national banks of Bank of America, First Citizens Bank, and Wells Fargo have the largest number of branches within the state. Of the many regional South Carolina banks, Truist and United Community Bank are the most popular. Take a look at the list of banks we have put together and see which one is the best South Carolina bank to help you with your finances.